UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


SCHEDULE 13G

Under the Securities Exchange Act of 1934


Amendment No.: 2*


Name of Issuer: STERIS Corporation


Title of Class of Securities: Common Shares


CUSIP Number: 85915210-0


Date of Event Which Requires Filing of this Statement: 12/31/2005


Check the appropriate box to designate the rule pursuant to which
this Schedule is filed.

[X] Rule 13d-1(b)
[ ] Rule 13d-1(c)
[ ] Rule 13d-1(d)

* The remainder of this cover page shall be filled out for a
reporting person's initial filing on this form with respect to the
subject class of securities, and for any subsequent amendment
containing information which would alter the disclosures provided
in a prior cover page.

The information required in the remainder of this cover page shall
not be deemed to be "filed" for the purpose of Section 18 of the
Securities Exchange Act of 1934 ("Act") or otherwise subject to
the liabilities of that section of the Act but shall be subject to
all other provisions of the Act (however, see the Notes).


CUSIP No.: 85915210-0

1.  NAME OF REPORTING PERSON
    S.S. OR I.R.S. IDENTIFICATION NO. OF ABOVE PERSON
    Mac-Per-Wolf Company
    EIN #36-3099763

2.  CHECK THE APPROPRIATE BOX IF A MEMBER OF A GROUP
    a.   ___
    b.   ___

3.  SEC USE ONLY

4.  CITIZENSHIP OR PLACE OF ORGANIZATION
         Delaware

NUMBER OF SHARES BENEFICIALLY OWNED BY EACH REPORTING PERSON WITH:

    5.   SOLE VOTING POWER
         67,272

    6.   SHARED VOTING POWER
         -2,920,776-

    7.   SOLE DISPOSITIVE POWER
         67,272

    8.   SHARED DISPOSITIVE POWER
         -2,920,776-

    9.   AGGREGATE AMOUNT BENEFICIALLY OWNED BY EACH REPORTING
PERSON
         2,988,048

    10.  CHECK BOX IF THE AGGREGATE AMOUNT IN ROW (9) EXCLUDES
CERTAIN SHARES
         Not applicable

11. PERCENT OF CLASS REPRESENTED BY AMOUNT IN ROW (9)
    4.4%

12. TYPE OF REPORTING PERSON
    HC



Item 1.

    (a). Name of Issuer: STERIS Corporation ("STERIS")

    (b). Address of Issuer's Principal Executive Offices:

         5960 Heisley Road
         Mentor, OH 44060-1834

Item 2.

    (a).-(c). Name, Principal Business Address, and Citizenship of
Persons
              Filing:

         (1)  Mac-Per-Wolf Company
              311 S. Wacker Dr., Suite 6000
              Chicago, IL  60606
              Citizenship:  Delaware

    (d). Title of Class of Securities:  Common Shares

    (e). CUSIP Number:  85915210-0

Item 3.

This statement is filed pursuant to Rule 13d-1 (b) and the person
filing, Mac-Per-Wolf Company, is a parent holding company in
accordance with 240.13d-1(b)(1)(ii)(G). See Item 7 for additional
information.

Item 4.  Ownership

The information in items 1 and 5 through 11 on the cover page(s)
on Schedule 13G is hereby incorporated by reference.

Perkins, Wolf, McDonnell and Company, LLC furnishes investment
advice to various investment companies registered under Section 8
of the Investment Company Act of 1940 and to individual and
institutional clients (collectively referred to herein as "Managed
Portfolios").

The shared voting and dispositive holdings are held by Perkins,
Wolf, McDonnell and Company, LLC, and such holdings may also be
aggregated within 13g filings submitted by Janus Capital
Management, LLC, a minority owner of Perkins, Wolf, McDonnell and
Company, LLC.

Item 5.  Ownership of Five Percent or Less of a Class

The Managed Portfolios, set forth in Item 4 above, have the right
to receive all dividends from, and the proceeds from the sale of,
the securities held in their respective accounts.

This statement is being filed to report the fact that the
reporting persons have ceased to be the beneficial owners of more
than five percent of the class of securities.

Item 6.  Ownership of More than Five Percent on Behalf of Another
Person

Not applicable.

Item 7.  Identification and Classification of the Subsidiary Which
Acquired the Security Being Reported on by the Parent Holding
Company

The reporting person, Mac-Per-Wolf Company, is filing on behalf of
its two subsidiaries:

1)   PWMCO, LLC is a wholly-owned subsidiary of Mac-Per-Wolf
Company and is both a broker dealer registered under Section 15 of
the Act and an investment adviser registered under Section 203 of
the Investment Advisers Act of 1940

2)   Perkins, Wolf, McDonnell and Company, LLC is a subsidiary of
Mac-Per-Wolf Company, and is an investment adviser registered
under Section 203 of the Investment Advisers Act of 1940

Item 8.  Identification and Classification of Members of the Group

Not applicable.

Item 9.  Notice of Dissolution of Group

Not applicable.

Item 10. Certification

By signing below I certify that, to the best of my knowledge and
belief, the securities referred to above were acquired in the
ordinary course of business and were not acquired for the purpose
of and do not have the effect of changing or influencing the
control of the issuer of such securities and were not acquired in
connection with or as a participant in any transaction having such
purposes or effect.


SIGNATURES

After reasonable inquiry and to the best of my knowledge and
belief, I certify that the information set forth in this statement
is true, complete and correct.

Mac-Per-Wolf Company

By  /s/  Gregory E. Wolf                       2/1/2006
  Gregory E. Wolf,                               Date
    Treasurer

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