United States securities and exchange commission logo March 9, 2021 J. Adam Zangerle Senior Vice President, General Counsel & Secretary STERIS plc 70 Sir John Rogerson s Quay Dublin 2 Ireland Re: STERIS plc Registration Statement on Form S-4 Filed March 2, 2021 File No. 333-253799 Dear Mr. Zangerle: This is to advise you that we have not reviewed and will not review your registration statement. Please refer to Rules 460 and 461 regarding requests for acceleration. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Please contact Dillon Hagius at 212-551-7976 with any questions. Sincerely, Division of Corporation Finance Office of Life Sciences cc: Peter C. Zwick