November 14, 2018 Via E-mail Walter M Rosebrough, Jr. President and Chief Executive Officer STERIS plc Rutherford House, Stephensons Way Chaddesden, Derby DE21 6LY United Kingdom Re: STERIS plc Form 10-K for the Fiscal Year Ended March 31, 2018 Filed May 30, 2018 File No. 1-37614 Dear Mr. Rosebrough: We refer you to our comment letter dated October 16, 2018, regarding business contacts with Syria. We have completed our review of this subject matter. We remind you that the company and its management are responsible for the accuracy and adequacy of their disclosures, notwithstanding any review, comments, action or absence of action by the staff. Sincerely, /s/ Cecilia Blye Cecilia Blye, Chief Office of Global Security Risk cc: Amanda Ravitz Assistant Director Division of Corporation Finance