<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:f66f4877-e854-41d2-95ea-98ddd737d913,g:500bdc4a-96bb-4f51-8f72-a20f54a85cea-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDBALANCESHEETSunaudited" xlink:type="simple" xlink:href="ste-20211231.xsd#CONSOLIDATEDBALANCESHEETSunaudited"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDBALANCESHEETSunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_OperatingAndFinanceLeaseObligationNoncurrent_75ab753c-efc4-4b60-962a-06f8e219d7b5" xlink:href="ste-20211231.xsd#ste_OperatingAndFinanceLeaseObligationNoncurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:to="loc_ste_OperatingAndFinanceLeaseObligationNoncurrent_75ab753c-efc4-4b60-962a-06f8e219d7b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_b3da20b3-122e-467e-ac41-bdf66ce609b1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:to="loc_us-gaap_DeferredIncomeTaxesAndOtherTaxLiabilitiesNoncurrent_b3da20b3-122e-467e-ac41-bdf66ce609b1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_d79d6515-ca45-4945-b632-0f821340a75d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_d79d6515-ca45-4945-b632-0f821340a75d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_7162c926-972c-478e-a6c2-84f07f8c5b25" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:to="loc_us-gaap_LiabilitiesCurrent_7162c926-972c-478e-a6c2-84f07f8c5b25" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherLiabilitiesNoncurrent_6c8b616d-69c9-47ce-8025-add2db39c92a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherLiabilitiesNoncurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Liabilities_e7e4ccfc-7978-41c6-8271-d2d8d65482a8" xlink:to="loc_us-gaap_OtherLiabilitiesNoncurrent_6c8b616d-69c9-47ce-8025-add2db39c92a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a5ddfac1-d16e-4268-994f-f35c6208e6fb" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_1f3fedee-43c3-44e7-ad38-034e7219f0ed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a5ddfac1-d16e-4268-994f-f35c6208e6fb" xlink:to="loc_us-gaap_StockholdersEquity_1f3fedee-43c3-44e7-ad38-034e7219f0ed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MinorityInterest_7fb14b67-868e-4c50-8c9f-2d35370c02e6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MinorityInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_a5ddfac1-d16e-4268-994f-f35c6208e6fb" xlink:to="loc_us-gaap_MinorityInterest_7fb14b67-868e-4c50-8c9f-2d35370c02e6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Assets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_c5c74bf5-6c98-46d5-82a0-7fa4f7e76b7c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_AssetsCurrent_c5c74bf5-6c98-46d5-82a0-7fa4f7e76b7c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_b932af50-9941-4cef-b48c-f74567b4575d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_b932af50-9941-4cef-b48c-f74567b4575d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherAssetsNoncurrent_deff558c-cfb1-40e5-89c6-e144d116559d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherAssetsNoncurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_OtherAssetsNoncurrent_deff558c-cfb1-40e5-89c6-e144d116559d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_e4157f39-672c-4d48-a6f5-8d46390902e4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_e4157f39-672c-4d48-a6f5-8d46390902e4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_9f8f1575-afe0-4a3e-a778-e0b1fcd64dc3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_Goodwill_9f8f1575-afe0-4a3e-a778-e0b1fcd64dc3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2caf63fc-70e1-407a-88e2-dfd8d9e25d56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IntangibleAssetsNetExcludingGoodwill"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_Assets_3d22f2e6-1de5-4a82-b42a-fe3e27fadc52" xlink:to="loc_us-gaap_IntangibleAssetsNetExcludingGoodwill_2caf63fc-70e1-407a-88e2-dfd8d9e25d56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_1d9fa81e-9447-404d-a5e0-0a1e4d901232" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_1d9fa81e-9447-404d-a5e0-0a1e4d901232" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_9c1446db-9285-4fdd-9e92-071854d56e27" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_9c1446db-9285-4fdd-9e92-071854d56e27" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_459f6918-ba04-47a4-bc5b-13ffec2efb34" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_ShortTermBorrowings_459f6918-ba04-47a4-bc5b-13ffec2efb34" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_4f7dea30-cf61-4ce8-82ec-f7fb63124c52" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_4f7dea30-cf61-4ce8-82ec-f7fb63124c52" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedIncomeTaxesCurrent_c9029bb0-8e19-4b0e-acf2-2d6c4a6b6ce3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccruedIncomeTaxesCurrent"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_AccruedIncomeTaxesCurrent_c9029bb0-8e19-4b0e-acf2-2d6c4a6b6ce3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_314d8d91-0759-49df-aac6-e0feed8db7fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesCurrent_9b556ae2-688f-457e-a9d2-66b08ffe4b13" xlink:to="loc_us-gaap_AccountsPayableCurrent_314d8d91-0759-49df-aac6-e0feed8db7fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_faea13a0-4bc8-40d1-8e32-4dfce84ef40f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AssetsCurrent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_ff6a305c-c00d-442f-b7ca-926de0369fa1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_faea13a0-4bc8-40d1-8e32-4dfce84ef40f" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_ff6a305c-c00d-442f-b7ca-926de0369fa1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_d9a04335-da9b-4cfd-b4f1-8459f61dc1e7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_faea13a0-4bc8-40d1-8e32-4dfce84ef40f" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_d9a04335-da9b-4cfd-b4f1-8459f61dc1e7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_1d17da87-c14a-4e99-be89-b28c70e32642" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_faea13a0-4bc8-40d1-8e32-4dfce84ef40f" xlink:to="loc_us-gaap_InventoryNet_1d17da87-c14a-4e99-be89-b28c70e32642" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherPrepaidExpenseCurrent_bd346780-8fde-41fd-8745-83e2a555994f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherPrepaidExpenseCurrent"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_AssetsCurrent_faea13a0-4bc8-40d1-8e32-4dfce84ef40f" xlink:to="loc_us-gaap_OtherPrepaidExpenseCurrent_bd346780-8fde-41fd-8745-83e2a555994f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7db16d-6866-493d-aac0-011cb6d0e63b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_718ea9e9-29f5-41c5-8339-317e8c301dbf" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Liabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7db16d-6866-493d-aac0-011cb6d0e63b" xlink:to="loc_us-gaap_Liabilities_718ea9e9-29f5-41c5-8339-317e8c301dbf" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_aaca9ecb-1201-42ba-af70-ab183b762216" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7db16d-6866-493d-aac0-011cb6d0e63b" xlink:to="loc_us-gaap_StockholdersEquityIncludingPortionAttributableToNoncontrollingInterest_aaca9ecb-1201-42ba-af70-ab183b762216" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_c031d960-f281-40af-ace7-ed77efbcfcae" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquity_cf7db16d-6866-493d-aac0-011cb6d0e63b" xlink:to="loc_us-gaap_CommitmentsAndContingencies_c031d960-f281-40af-ace7-ed77efbcfcae" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_d6af2832-ab1f-4f6b-9dc3-d0f56011e9df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_StockholdersEquity"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_a714c691-fb3b-4e57-8381-e4d45a6a1b57" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CommonStockValue"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d6af2832-ab1f-4f6b-9dc3-d0f56011e9df" xlink:to="loc_us-gaap_CommonStockValue_a714c691-fb3b-4e57-8381-e4d45a6a1b57" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_f4c9fa0d-a157-4cca-bcd1-b955f0bc0e8c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d6af2832-ab1f-4f6b-9dc3-d0f56011e9df" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_f4c9fa0d-a157-4cca-bcd1-b955f0bc0e8c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0fe371e7-4ab6-441a-9f38-00654447f203" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_StockholdersEquity_d6af2832-ab1f-4f6b-9dc3-d0f56011e9df" xlink:to="loc_us-gaap_AccumulatedOtherComprehensiveIncomeLossNetOfTax_0fe371e7-4ab6-441a-9f38-00654447f203" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSunaudited" xlink:type="simple" xlink:href="ste-20211231.xsd#CONSOLIDATEDSTATEMENTSOFOPERATIONSunaudited"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFOPERATIONSunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_adbbc0fc-426c-44d8-8d37-4947a938445e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Revenues_b1e96758-7717-4a0f-82db-d71e626d79ee" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Revenues"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_adbbc0fc-426c-44d8-8d37-4947a938445e" xlink:to="loc_us-gaap_Revenues_b1e96758-7717-4a0f-82db-d71e626d79ee" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_57efa99a-8715-41f3-8654-00984872e26a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfRevenue"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_GrossProfit_adbbc0fc-426c-44d8-8d37-4947a938445e" xlink:to="loc_us-gaap_CostOfRevenue_57efa99a-8715-41f3-8654-00984872e26a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_b05bb9e0-88ae-4b48-92cb-16b1c0c280df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SellingGeneralAndAdministrativeExpense_a51232bd-4e8a-4922-b1ed-98b1b348a288" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SellingGeneralAndAdministrativeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_b05bb9e0-88ae-4b48-92cb-16b1c0c280df" xlink:to="loc_us-gaap_SellingGeneralAndAdministrativeExpense_a51232bd-4e8a-4922-b1ed-98b1b348a288" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_a5b7e5da-c685-4ada-9c34-04e792ec4289" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_b05bb9e0-88ae-4b48-92cb-16b1c0c280df" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_a5b7e5da-c685-4ada-9c34-04e792ec4289" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestructuringCosts_4279630c-57d5-463d-86b2-eddbf3368474" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RestructuringCosts"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingExpenses_b05bb9e0-88ae-4b48-92cb-16b1c0c280df" xlink:to="loc_us-gaap_RestructuringCosts_4279630c-57d5-463d-86b2-eddbf3368474" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_dced62ce-8c27-429e-8471-dc1b1fb57e58" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_d3ef4930-dc3a-4e0c-82f8-e176fb7ad906" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_dced62ce-8c27-429e-8471-dc1b1fb57e58" xlink:to="loc_us-gaap_ProfitLoss_d3ef4930-dc3a-4e0c-82f8-e176fb7ad906" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_870dd532-7576-4bb1-9dba-414777384219" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_dced62ce-8c27-429e-8471-dc1b1fb57e58" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_870dd532-7576-4bb1-9dba-414777384219" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_8d9f8c71-ab8c-49dd-9ef1-b851572d3a93" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpense_66b82a76-3c98-41a0-ab59-1b9e2cac53df" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNonoperatingIncomeExpense"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_8d9f8c71-ab8c-49dd-9ef1-b851572d3a93" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpense_66b82a76-3c98-41a0-ab59-1b9e2cac53df" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_FairValueAdjustmentRelatedToConvertibleDebtLiability_d22121df-d581-4fe4-8e6c-c3cb51f1591d" xlink:href="ste-20211231.xsd#ste_FairValueAdjustmentRelatedToConvertibleDebtLiability"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_8d9f8c71-ab8c-49dd-9ef1-b851572d3a93" xlink:to="loc_ste_FairValueAdjustmentRelatedToConvertibleDebtLiability_d22121df-d581-4fe4-8e6c-c3cb51f1591d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_a0965f99-bc68-4d92-82af-a39af7ed0cb2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InterestExpense"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NonoperatingIncomeExpense_8d9f8c71-ab8c-49dd-9ef1-b851572d3a93" xlink:to="loc_us-gaap_InterestExpense_a0965f99-bc68-4d92-82af-a39af7ed0cb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfRevenue_26b8356f-0b60-4a16-b05f-150869ae8a01" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfRevenue"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CostOfGoodsAndServicesSold_6eb9babb-34ba-4bb4-ac66-de2a91526128" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CostOfGoodsAndServicesSold"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CostOfRevenue_26b8356f-0b60-4a16-b05f-150869ae8a01" xlink:to="loc_us-gaap_CostOfGoodsAndServicesSold_6eb9babb-34ba-4bb4-ac66-de2a91526128" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_5176c39b-8fc1-49b7-966e-fe9c8c79b0d1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_1161b0a8-d409-4e6d-a2a3-de0d06fc4e33" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingExpenses"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_5176c39b-8fc1-49b7-966e-fe9c8c79b0d1" xlink:to="loc_us-gaap_OperatingExpenses_1161b0a8-d409-4e6d-a2a3-de0d06fc4e33" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GrossProfit_23b7501e-a2e2-47ae-a165-514382e0ebb2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GrossProfit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OperatingIncomeLoss_5176c39b-8fc1-49b7-966e-fe9c8c79b0d1" xlink:to="loc_us-gaap_GrossProfit_23b7501e-a2e2-47ae-a165-514382e0ebb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_8bc98377-fb35-4885-915e-df7a2a69f3f5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e1219cef-adf7-47e1-88ee-409cf921d308" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8bc98377-fb35-4885-915e-df7a2a69f3f5" xlink:to="loc_us-gaap_IncomeLossFromContinuingOperationsBeforeIncomeTaxesExtraordinaryItemsNoncontrollingInterest_e1219cef-adf7-47e1-88ee-409cf921d308" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_ed19b3d1-12bd-422a-ba4b-bbe89738a413" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ProfitLoss_8bc98377-fb35-4885-915e-df7a2a69f3f5" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_ed19b3d1-12bd-422a-ba4b-bbe89738a413" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEunaudited" xlink:type="simple" xlink:href="ste-20211231.xsd#CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEunaudited"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCOMPREHENSIVEINCOMEunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_73aa76c8-d3a2-45f2-84f5-a1847b64edc6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_b03d520a-5cfb-4591-a493-8005097856c4" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_73aa76c8-d3a2-45f2-84f5-a1847b64edc6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeDefinedBenefitPlansNetUnamortizedGainLossArisingDuringPeriodNetOfTax_b03d520a-5cfb-4591-a493-8005097856c4" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_24e6dd93-72e5-485a-9694-d02f0117559d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_73aa76c8-d3a2-45f2-84f5-a1847b64edc6" xlink:to="loc_us-gaap_OtherComprehensiveIncomeForeignCurrencyTransactionAndTranslationGainLossArisingDuringPeriodNetOfTax_24e6dd93-72e5-485a-9694-d02f0117559d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_9be09cc9-ebee-476d-a23e-20272711ea63" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_32bf1e34-52bb-4c07-97a0-06c3b40a0c45" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_9be09cc9-ebee-476d-a23e-20272711ea63" xlink:to="loc_us-gaap_ProfitLoss_32bf1e34-52bb-4c07-97a0-06c3b40a0c45" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_91bbe4a2-6c98-4519-941a-2cc13c77d837" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLossAttributableToNoncontrollingInterest"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetIncomeLoss_9be09cc9-ebee-476d-a23e-20272711ea63" xlink:to="loc_us-gaap_NetIncomeLossAttributableToNoncontrollingInterest_91bbe4a2-6c98-4519-941a-2cc13c77d837" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_f4ddeae1-ea6e-4f77-ba17-7b3cee42d981" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_491f13fa-1b38-40b4-8108-6c2431f19363" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_f4ddeae1-ea6e-4f77-ba17-7b3cee42d981" xlink:to="loc_us-gaap_OtherComprehensiveIncomeLossNetOfTaxPortionAttributableToParent_491f13fa-1b38-40b4-8108-6c2431f19363" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_074438f7-a7dd-4c1e-8569-dd1264d73a2c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetIncomeLoss"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ComprehensiveIncomeNetOfTax_f4ddeae1-ea6e-4f77-ba17-7b3cee42d981" xlink:to="loc_us-gaap_NetIncomeLoss_074438f7-a7dd-4c1e-8569-dd1264d73a2c" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited" xlink:type="simple" xlink:href="ste-20211231.xsd#CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/CONSOLIDATEDSTATEMENTSOFCASHFLOWSunaudited" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToMinorityShareholders_1ae4dbed-4eba-4322-9f91-b2538e7585d5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToMinorityShareholders"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_PaymentsToMinorityShareholders_1ae4dbed-4eba-4322-9f91-b2538e7585d5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfDividendsCommonStock_b179bbc6-c09f-4de4-902e-541598d6392f" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfDividendsCommonStock"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_PaymentsOfDividendsCommonStock_b179bbc6-c09f-4de4-902e-541598d6392f" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_dddbaac5-a767-4644-9601-49a275945727" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromRepaymentsOfLinesOfCredit"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_ProceedsFromRepaymentsOfLinesOfCredit_dddbaac5-a767-4644-9601-49a275945727" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_d4dd0719-bec0-4453-837a-7032d20bcce8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromPaymentsForOtherFinancingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_ProceedsFromPaymentsForOtherFinancingActivities_d4dd0719-bec0-4453-837a-7032d20bcce8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMinorityShareholders_e9e66036-fb12-4f85-95c3-6dd08d24ec24" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromMinorityShareholders"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_ProceedsFromMinorityShareholders_e9e66036-fb12-4f85-95c3-6dd08d24ec24" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_8855d01d-d84a-493c-920c-c442c5737ace" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_8855d01d-d84a-493c-920c-c442c5737ace" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfConvertibleDebt_d8ae02ac-98b8-4e33-825b-13c6d0d9a3d7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfConvertibleDebt"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_RepaymentsOfConvertibleDebt_d8ae02ac-98b8-4e33-825b-13c6d0d9a3d7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSeniorDebt_9a859df0-5d52-48f0-9749-051e27eb0035" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfSeniorDebt"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_RepaymentsOfSeniorDebt_9a859df0-5d52-48f0-9749-051e27eb0035" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_PaymentsForAcquisitionOfSubsidiaryInterestsInNoncontrollingInterest_65e8b4fc-a4c6-4294-88af-673e94251396" xlink:href="ste-20211231.xsd#ste_PaymentsForAcquisitionOfSubsidiaryInterestsInNoncontrollingInterest"/>
    <link:calculationArc order="9" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_ste_PaymentsForAcquisitionOfSubsidiaryInterestsInNoncontrollingInterest_65e8b4fc-a4c6-4294-88af-673e94251396" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_c00e9ffc-e08f-483a-a32a-c03bd0596fad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities"/>
    <link:calculationArc order="10" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_PaymentsOfMergerRelatedCostsFinancingActivities_c00e9ffc-e08f-483a-a32a-c03bd0596fad" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RepaymentsOfSecuredDebt_a44e2c93-38d5-4f86-a953-a72a40dbd3d8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_RepaymentsOfSecuredDebt"/>
    <link:calculationArc order="11" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_RepaymentsOfSecuredDebt_a44e2c93-38d5-4f86-a953-a72a40dbd3d8" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfFinancingCosts_8944c50a-7564-428a-832f-b643f5cd5c89" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsOfFinancingCosts"/>
    <link:calculationArc order="12" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_PaymentsOfFinancingCosts_8944c50a-7564-428a-832f-b643f5cd5c89" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_da0dc166-9a36-43d4-a0e2-f05078bf2c56" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForRepurchaseOfCommonStock"/>
    <link:calculationArc order="13" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_PaymentsForRepurchaseOfCommonStock_da0dc166-9a36-43d4-a0e2-f05078bf2c56" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt_5750e1b3-3c8c-405d-bdfa-d3b4d6532654" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_15792da0-83ce-4e95-946e-d10094d99c41" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSeniorLongTermDebt_5750e1b3-3c8c-405d-bdfa-d3b4d6532654" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_5ffa4867-e687-4188-9e0f-9603f7803b9c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_5ffa4867-e687-4188-9e0f-9603f7803b9c" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ffa17cb5-3292-4136-b55e-27f777a76451" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidDeferredExpenseAndOtherAssets_ffa17cb5-3292-4136-b55e-27f777a76451" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ef83c294-b160-412f-b53a-4c8f072317a0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_ef83c294-b160-412f-b53a-4c8f072317a0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInInventories_03af25e3-daef-4df4-9f50-e38f65188c14" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInInventories"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_IncreaseDecreaseInInventories_03af25e3-daef-4df4-9f50-e38f65188c14" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b70d4423-1a50-43e9-8912-99ee111ba63d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:calculationArc order="5" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_b70d4423-1a50-43e9-8912-99ee111ba63d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNoncashIncomeExpense_8744db2d-ed69-4a7b-a44d-185c79e6629a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OtherNoncashIncomeExpense"/>
    <link:calculationArc order="6" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_OtherNoncashIncomeExpense_8744db2d-ed69-4a7b-a44d-185c79e6629a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfBusiness_ef1523a9-2a5c-4ef2-8e68-1c100978a866" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfBusiness"/>
    <link:calculationArc order="7" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_GainLossOnSaleOfBusiness_ef1523a9-2a5c-4ef2-8e68-1c100978a866" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_d6ce719b-7c67-4bc0-a17b-0796c3b3a745" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_GainLossOnSaleOfPropertyPlantEquipment"/>
    <link:calculationArc order="8" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_GainLossOnSaleOfPropertyPlantEquipment_d6ce719b-7c67-4bc0-a17b-0796c3b3a745" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_32e66d5e-3854-4e1d-801d-a7b53f172bf9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShareBasedCompensation"/>
    <link:calculationArc order="9" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_ShareBasedCompensation_32e66d5e-3854-4e1d-801d-a7b53f172bf9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_51250a57-ab36-48f2-b119-c91eaa776ebe" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredIncomeTaxExpenseBenefit"/>
    <link:calculationArc order="10" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_DeferredIncomeTaxExpenseBenefit_51250a57-ab36-48f2-b119-c91eaa776ebe" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DepreciationDepletionAndAmortization_39c6716f-4fb3-4218-8a2d-669b195ee55d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DepreciationDepletionAndAmortization"/>
    <link:calculationArc order="11" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_DepreciationDepletionAndAmortization_39c6716f-4fb3-4218-8a2d-669b195ee55d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfitLoss_3221cd63-39ba-43e1-88cf-0bfc7966ba51" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProfitLoss"/>
    <link:calculationArc order="12" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_us-gaap_ProfitLoss_3221cd63-39ba-43e1-88cf-0bfc7966ba51" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_FairValueAdjustmentRelatedToConvertibleDebtLiability_a96a3789-5d85-45ca-95e3-6e443f3a2e07" xlink:href="ste-20211231.xsd#ste_FairValueAdjustmentRelatedToConvertibleDebtLiability"/>
    <link:calculationArc order="13" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_ste_FairValueAdjustmentRelatedToConvertibleDebtLiability_a96a3789-5d85-45ca-95e3-6e443f3a2e07" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_AmortizationOfInventoryFairValueAdjustments_ec431af6-b490-4370-a8e7-dca8ec90c336" xlink:href="ste-20211231.xsd#ste_AmortizationOfInventoryFairValueAdjustments"/>
    <link:calculationArc order="14" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_7feacf7b-7765-43e9-adf9-a40af2d1ad22" xlink:to="loc_ste_AmortizationOfInventoryFairValueAdjustments_ec431af6-b490-4370-a8e7-dca8ec90c336" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1f6a6431-c44c-499a-8dae-2f1d4c0dccc1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0684ba88-161d-4d77-b135-f4a63ec486ab" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1f6a6431-c44c-499a-8dae-2f1d4c0dccc1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_0684ba88-161d-4d77-b135-f4a63ec486ab" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dcab17d3-03e5-4f14-967f-a3c35a6a4265" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1f6a6431-c44c-499a-8dae-2f1d4c0dccc1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_dcab17d3-03e5-4f14-967f-a3c35a6a4265" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_c17d1f0e-5a6e-42bf-ab7c-0ce311b6f1d3" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1f6a6431-c44c-499a-8dae-2f1d4c0dccc1" xlink:to="loc_us-gaap_EffectOfExchangeRateOnCashAndCashEquivalents_c17d1f0e-5a6e-42bf-ab7c-0ce311b6f1d3" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e04cff22-6e7f-45ae-a977-03036360b33d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_1f6a6431-c44c-499a-8dae-2f1d4c0dccc1" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_e04cff22-6e7f-45ae-a977-03036360b33d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2613f12-9fe1-4910-9ab5-3ea723bbffc2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_66e18719-a4b5-407b-be44-a07bddf75af5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:calculationArc order="1" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2613f12-9fe1-4910-9ab5-3ea723bbffc2" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_66e18719-a4b5-407b-be44-a07bddf75af5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_9a06fdda-1780-4e8c-838a-0674487ebae9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2613f12-9fe1-4910-9ab5-3ea723bbffc2" xlink:to="loc_us-gaap_ProceedsFromSaleOfPropertyPlantAndEquipment_9a06fdda-1780-4e8c-838a-0674487ebae9" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_d593605e-370f-475f-a05c-1be4b802866b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2613f12-9fe1-4910-9ab5-3ea723bbffc2" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesNetOfCashAcquired_d593605e-370f-475f-a05c-1be4b802866b" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_af7e0baf-9a8f-4324-b26c-64d9160d5134" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsForProceedsFromOtherInvestingActivities"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_a2613f12-9fe1-4910-9ab5-3ea723bbffc2" xlink:to="loc_us-gaap_PaymentsForProceedsFromOtherInvestingActivities_af7e0baf-9a8f-4324-b26c-64d9160d5134" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessAcquisitionsandDivestituresRevenuesTotalPurchaseConsiderationsDetails" xlink:type="simple" xlink:href="ste-20211231.xsd#BusinessAcquisitionsandDivestituresRevenuesTotalPurchaseConsiderationsDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/BusinessAcquisitionsandDivestituresRevenuesTotalPurchaseConsiderationsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferred1"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireBusinessesGross_9836afb2-0928-491a-934f-72bfc6cce3fd" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PaymentsToAcquireBusinessesGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:to="loc_us-gaap_PaymentsToAcquireBusinessesGross_9836afb2-0928-491a-934f-72bfc6cce3fd" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredOther1_9dff9a76-3c99-4ba9-9548-3ccd0be06990" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredOther1"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredOther1_9dff9a76-3c99-4ba9-9548-3ccd0be06990" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_dd293b4c-c219-48b1-a6bb-93023e9b50c7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:to="loc_us-gaap_BusinessCombinationConsiderationTransferredEquityInterestsIssuedAndIssuable_dd293b4c-c219-48b1-a6bb-93023e9b50c7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ConsiderationTransferredEquityAwardsIssuedAndIssuable_82517c0f-1330-4c0d-836b-b12adc569559" xlink:href="ste-20211231.xsd#ste_ConsiderationTransferredEquityAwardsIssuedAndIssuable"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:to="loc_ste_ConsiderationTransferredEquityAwardsIssuedAndIssuable_82517c0f-1330-4c0d-836b-b12adc569559" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_ConsiderationRelatedToEquityComponentOfConvertibleDebt_36a4cd28-4d96-4472-b72d-53a6980b516f" xlink:href="ste-20211231.xsd#ste_ConsiderationRelatedToEquityComponentOfConvertibleDebt"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationConsiderationTransferred1_3eaa747a-85c1-4cc0-86b5-2eef19727cbd" xlink:to="loc_ste_ConsiderationRelatedToEquityComponentOfConvertibleDebt_36a4cd28-4d96-4472-b72d-53a6980b516f" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/BusinessAcquisitionsandDivestituresFairValueofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="simple" xlink:href="ste-20211231.xsd#BusinessAcquisitionsandDivestituresFairValueofAssetsAcquiredandLiabilitiesAssumedDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/BusinessAcquisitionsandDivestituresFairValueofAssetsAcquiredandLiabilitiesAssumedDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_BusinessCombinationConvertibleDebtParValueAssumed_6a3ead1d-2c6c-445d-a1c4-1fd04d8f1b32" xlink:href="ste-20211231.xsd#ste_BusinessCombinationConvertibleDebtParValueAssumed"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:to="loc_ste_BusinessCombinationConvertibleDebtParValueAssumed_6a3ead1d-2c6c-445d-a1c4-1fd04d8f1b32" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_3fe1d771-7e5c-4d4f-899e-86c1fefc431d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentLiabilities_3fe1d771-7e5c-4d4f-899e-86c1fefc431d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_19eb02cf-bb3b-4a83-aa24-6a7f903954c5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCapitalLeaseObligation_19eb02cf-bb3b-4a83-aa24-6a7f903954c5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_727b492b-baf6-4c06-b436-57205b329367" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedDeferredTaxLiabilities_727b492b-baf6-4c06-b436-57205b329367" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_BusinessCombinationLongTermObligationsAssumed_5bad664c-4d4d-4f4d-b17c-0936a3b48456" xlink:href="ste-20211231.xsd#ste_BusinessCombinationLongTermObligationsAssumed"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_3bc241b0-fb19-4e9a-a4f9-5ba1fae83562" xlink:to="loc_ste_BusinessCombinationLongTermObligationsAssumed_5bad664c-4d4d-4f4d-b17c-0936a3b48456" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dc77de46-a2b3-43a0-97e0-f1faae27444a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCashAndEquivalents_dc77de46-a2b3-43a0-97e0-f1faae27444a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_46584ee4-b7df-4321-9c5e-3b2755304820" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsReceivables_46584ee4-b7df-4321-9c5e-3b2755304820" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_26760cbd-fe75-444d-95a7-b9e69568424d" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedInventory_26760cbd-fe75-444d-95a7-b9e69568424d" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6c78e88b-1062-4e0d-b5b4-addcd63f3ff7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedPropertyPlantAndEquipment_6c78e88b-1062-4e0d-b5b4-addcd63f3ff7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_708462ef-ea49-4605-8ecc-517f7a26bac7" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_708462ef-ea49-4605-8ecc-517f7a26bac7" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_3ed70b28-8cae-48a6-8bd6-4aedb3fe699a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedCurrentAssetsOther_3ed70b28-8cae-48a6-8bd6-4aedb3fe699a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_0ee22564-f036-4ee1-bd19-5c4ef0d296b6" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedIntangibleAssetsOtherThanGoodwill_0ee22564-f036-4ee1-bd19-5c4ef0d296b6" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Goodwill_fdb4fa2f-9e66-44d8-b854-28b3d70ebfed" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Goodwill"/>
    <link:calculationArc order="8" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_7b3f5f63-2702-4cca-958e-558fe74b38d2" xlink:to="loc_us-gaap_Goodwill_fdb4fa2f-9e66-44d8-b854-28b3d70ebfed" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_1b1a7693-a395-4fe0-af86-75f67d7f9e20" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_d795668c-d033-403e-9646-dc73dfcf1401" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_1b1a7693-a395-4fe0-af86-75f67d7f9e20" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_d795668c-d033-403e-9646-dc73dfcf1401" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_7f9bdb0a-9779-4e98-ae24-d468c18f5ca8" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedNet_1b1a7693-a395-4fe0-af86-75f67d7f9e20" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_7f9bdb0a-9779-4e98-ae24-d468c18f5ca8" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/InventoriesNetInventoriesNetDetails" xlink:type="simple" xlink:href="ste-20211231.xsd#InventoriesNetInventoriesNetDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/InventoriesNetInventoriesNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryNet_6949d07e-b28e-43d3-812f-e1fee316b785" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryRawMaterials_eea45885-a3ae-4420-98b5-acd334e9787e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryRawMaterials"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6949d07e-b28e-43d3-812f-e1fee316b785" xlink:to="loc_us-gaap_InventoryRawMaterials_eea45885-a3ae-4420-98b5-acd334e9787e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryWorkInProcess_a04693a2-590d-44c1-99ef-3213b6e2e209" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryWorkInProcess"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6949d07e-b28e-43d3-812f-e1fee316b785" xlink:to="loc_us-gaap_InventoryWorkInProcess_a04693a2-590d-44c1-99ef-3213b6e2e209" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryFinishedGoods_91e841af-100a-4960-a684-2a5c6e025c61" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryFinishedGoods"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6949d07e-b28e-43d3-812f-e1fee316b785" xlink:to="loc_us-gaap_InventoryFinishedGoods_91e841af-100a-4960-a684-2a5c6e025c61" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InventoryValuationReserves_75f3b352-9c82-498f-bb94-9a38ff230b5b" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_InventoryValuationReserves"/>
    <link:calculationArc order="4" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_InventoryNet_6949d07e-b28e-43d3-812f-e1fee316b785" xlink:to="loc_us-gaap_InventoryValuationReserves_75f3b352-9c82-498f-bb94-9a38ff230b5b" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/PropertyPlantandEquipmentPropertyPlantandEquipmentDetails" xlink:type="simple" xlink:href="ste-20211231.xsd#PropertyPlantandEquipmentPropertyPlantandEquipmentDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/PropertyPlantandEquipmentPropertyPlantandEquipmentDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_7e814c3a-09e5-4884-ae20-7ec57c94704c" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_90ec89c9-f4a6-41a9-b35a-8c02e7717726" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_7e814c3a-09e5-4884-ae20-7ec57c94704c" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_90ec89c9-f4a6-41a9-b35a-8c02e7717726" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_5a1e0067-0a2e-40d2-8192-92888c4b8b85" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:calculationArc order="2" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentNet_7e814c3a-09e5-4884-ae20-7ec57c94704c" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_5a1e0067-0a2e-40d2-8192-92888c4b8b85" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Land_4cc1ebf6-2f37-4d0a-943c-be4cc576d616" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_Land"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_us-gaap_Land_4cc1ebf6-2f37-4d0a-943c-be4cc576d616" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BuildingsAndImprovementsGross_efa33346-d4bc-4214-8f0f-3ab94d194135" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_BuildingsAndImprovementsGross"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_us-gaap_BuildingsAndImprovementsGross_efa33346-d4bc-4214-8f0f-3ab94d194135" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MachineryAndEquipmentGross_0728508f-d03f-4bc3-88b9-46a41ecbc33e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MachineryAndEquipmentGross"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_us-gaap_MachineryAndEquipmentGross_0728508f-d03f-4bc3-88b9-46a41ecbc33e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MaterialsSuppliesAndOther_eab6bf6f-b9e4-4545-a053-26cf181101b2" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_MaterialsSuppliesAndOther"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_us-gaap_MaterialsSuppliesAndOther_eab6bf6f-b9e4-4545-a053-26cf181101b2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConstructionInProgressGross_299f9bec-4ddd-420b-9574-1ff4a99d33b0" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ConstructionInProgressGross"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_us-gaap_ConstructionInProgressGross_299f9bec-4ddd-420b-9574-1ff4a99d33b0" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_CapitalizedComputerHardwareSoftwareGross_607d2a51-1fcb-4725-9a3f-1fab690d66d1" xlink:href="ste-20211231.xsd#ste_CapitalizedComputerHardwareSoftwareGross"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentGross_7602cd7b-c448-4a63-a763-9ab4f07b98ad" xlink:to="loc_ste_CapitalizedComputerHardwareSoftwareGross_607d2a51-1fcb-4725-9a3f-1fab690d66d1" xlink:type="arc"/>
  </link:calculationLink>
  <link:roleRef roleURI="http://www.steris.com/role/DebtDebtDetails" xlink:type="simple" xlink:href="ste-20211231.xsd#DebtDebtDetails"/>
  <link:calculationLink xlink:role="http://www.steris.com/role/DebtDebtDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_206e18d5-9ab7-41ea-857b-7c6eb3d77265" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermBorrowings"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_TermLoanCurrentPortion_bb713086-fb3c-462c-996d-5f01f89f3a21" xlink:href="ste-20211231.xsd#ste_TermLoanCurrentPortion"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_206e18d5-9ab7-41ea-857b-7c6eb3d77265" xlink:to="loc_ste_TermLoanCurrentPortion_bb713086-fb3c-462c-996d-5f01f89f3a21" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_DelayedDrawTermLoanCurrentPortion_8cf1114c-d3d8-4f22-ac92-e2728cedddb2" xlink:href="ste-20211231.xsd#ste_DelayedDrawTermLoanCurrentPortion"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_206e18d5-9ab7-41ea-857b-7c6eb3d77265" xlink:to="loc_ste_DelayedDrawTermLoanCurrentPortion_8cf1114c-d3d8-4f22-ac92-e2728cedddb2" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorNotesCurrent_9318f3cb-559b-4411-ab0a-48213c8b7541" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorNotesCurrent"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_ShortTermBorrowings_206e18d5-9ab7-41ea-857b-7c6eb3d77265" xlink:to="loc_us-gaap_SeniorNotesCurrent_9318f3cb-559b-4411-ab0a-48213c8b7541" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeniorLongTermNotes_ddfa6589-3b30-46a0-9fa8-a24df9ce69fa" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_SeniorLongTermNotes"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_us-gaap_SeniorLongTermNotes_ddfa6589-3b30-46a0-9fa8-a24df9ce69fa" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCredit_46005123-3143-4d48-8d14-dce74397b010" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LineOfCredit"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_us-gaap_LineOfCredit_46005123-3143-4d48-8d14-dce74397b010" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DeferredFinanceCostsNet_c8837eb3-48f0-49af-9920-b361a3d82d9e" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DeferredFinanceCostsNet"/>
    <link:calculationArc order="3" weight="-1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_us-gaap_DeferredFinanceCostsNet_c8837eb3-48f0-49af-9920-b361a3d82d9e" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_TermLoanLongTermPortion_bec69568-8fb9-44ae-a896-db870758a2b5" xlink:href="ste-20211231.xsd#ste_TermLoanLongTermPortion"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_ste_TermLoanLongTermPortion_bec69568-8fb9-44ae-a896-db870758a2b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_DelayedDrawTermLoanLongTermPortion_5a757a77-e522-4029-97fb-b947b2474a6a" xlink:href="ste-20211231.xsd#ste_DelayedDrawTermLoanLongTermPortion"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_ste_DelayedDrawTermLoanLongTermPortion_5a757a77-e522-4029-97fb-b947b2474a6a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_5b819368-3e12-4f8e-9fc5-35a2679b2d0a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:calculationArc order="6" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_5b819368-3e12-4f8e-9fc5-35a2679b2d0a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiability_9f5734b9-5076-4769-9a72-1726d626107a" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_FinanceLeaseLiability"/>
    <link:calculationArc order="7" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_LongTermDebt_0b6d8346-5d00-48be-8358-01f2a6d90618" xlink:to="loc_us-gaap_FinanceLeaseLiability_9f5734b9-5076-4769-9a72-1726d626107a" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_35df8348-9a34-4dfb-bc8c-613680761b02" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_DebtLongtermAndShorttermCombinedAmount"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermBorrowings_a2765971-b0ec-4087-b052-8c973ff2e6dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_ShortTermBorrowings"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_35df8348-9a34-4dfb-bc8c-613680761b02" xlink:to="loc_us-gaap_ShortTermBorrowings_a2765971-b0ec-4087-b052-8c973ff2e6dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_d45ab7f3-b190-4efd-b3ec-1efc3baf99dc" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebt"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_us-gaap_DebtLongtermAndShorttermCombinedAmount_35df8348-9a34-4dfb-bc8c-613680761b02" xlink:to="loc_us-gaap_LongTermDebt_d45ab7f3-b190-4efd-b3ec-1efc3baf99dc" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:href="ste-20211231.xsd#ste_LongTermDebtExcludingDeferredFinancingFees"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_968c0a72-66f6-4652-9ebc-382d236c12b5" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:calculationArc order="1" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_968c0a72-66f6-4652-9ebc-382d236c12b5" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7697dd88-252d-47ab-9300-75e393e9e8a1" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:calculationArc order="2" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_7697dd88-252d-47ab-9300-75e393e9e8a1" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_6e42fd1f-0ef1-48fc-b1c3-b12c1fbc0404" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour"/>
    <link:calculationArc order="3" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFour_6e42fd1f-0ef1-48fc-b1c3-b12c1fbc0404" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_40936def-3272-4ee6-b92e-1782fe186572" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive"/>
    <link:calculationArc order="4" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearFive_40936def-3272-4ee6-b92e-1782fe186572" xlink:type="arc"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_1229121c-65c5-42df-89a1-453d9c0b54d9" xlink:href="https://xbrl.fasb.org/us-gaap/2021/elts/us-gaap-2021-01-31.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive"/>
    <link:calculationArc order="5" weight="1.0" xlink:arcrole="http://www.xbrl.org/2003/arcrole/summation-item" xlink:from="loc_ste_LongTermDebtExcludingDeferredFinancingFees_036b0c6f-f16e-4cb8-b7ef-3f87cb4e3347" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalAfterYearFive_1229121c-65c5-42df-89a1-453d9c0b54d9" xlink:type="arc"/>
  </link:calculationLink>
</link:linkbase>
